The phagocytosis-stimulating factor produced by phagocytosing neutrophils
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چکیده
منابع مشابه
Phagocytosing Human Neutrophils
A B S T R A C T During phagocytosis, neutrophils generate reactive oxygen metabolites and release lysosomal enzymes into the extracellular medium. We have investigated the possibility that these enzymes are inactivated by the oxygen compounds. Phagocytosing neutrophils from 12 patients with chronic granulomatous disease, which do not generate these oxygen metabolites, released two to three time...
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A precursor of phagocytosis-stimulating factor (PSF) was identified by immunoblot assay with purified anti-PSF antibodies. The purified anti-PSF antibodies recognized not only the PSF with a molecular weight of 16,000 (16K) but also the 36K protein with a pI of 6.5 in the granule fraction of polymorphonuclear neutrophils, indicating that this 36K protein has an antigenic determinant common to P...
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The tripeptide y-glutamyl-cysteinyl-glycine. or glutathione. protects cells against oxidative damage by its ability to react with free radicals and peroxides. From studies with human neutrophilic granulocytes deficient in glutathione metabolism. it is known that the protection by this compound is essential for the proper functioning of these cells. Previous studies have yielded conflicting esti...
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Phagocytosis is central to the microbicidal function of neutrophils. Pathogens are initially engulfed into a plasma membrane-derived vacuole, the phagosome, which proceeds to acquire degradative properties by a complex process termed maturation. In this chapter, we discuss the current knowledge of the molecular mechanisms underlying phagosome formation and maturation in neutrophils. © 2003 Édit...
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ژورنال
عنوان ژورنال: Ensho
سال: 1981
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.1.53